Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

David Kellogg Lewis (1941-2001) was one of the most influential philosophers of the twentieth century. He made significant contributions to almost every area of analytic philosophy including metaphysics, philosophy of language, philosophy of mind, and philosophy of science, and set the agenda for various debates in these areas which carry on to this day. In several respects he remains a contemporary figure, yet enough time has now passed for historians of philosophy to begin to study his place in (...) twentieth century thought. His philosophy was constructed and refined not just through his published writing, but also crucially through his life-long correspondence with fellow philosophers, including leading figures such as D.M. Armstrong, Saul Kripke, W.V. Quine, J.J.C. Smart, and Peter van Inwagen. His letters formed the undercurrent of his published work and became the medium through which he proposed many of his well-known theories and discussed a range of philosophical topics in depth. A selection of his vast correspondence over a 40-year period is presented here across two volumes. The letters offer an organic story of the origins, development, breadth, and depth of his philosophy in its historical context, as well as a glimpse into the influence of his many interlocutors."-- OCLC OLUC. (shrink)

Few figures of the Middle Ages command the attention of so many modern disciplines as Robert Grosseteste (c. 1170-1253). Theology, Philosophy, History, and Science are all areas which his life and thought continue to have significance and to inspire re-interpretation. Accompanied by a series of original commentaries, this new edition of Grosseteste's work, with English translation, draws together the perspectives of modern scientists and medieval specialists. Volume I of a six volume series, Knowing and Speaking presents two of the earliest (...) of Grosseteste's works, the treatises On the Liberal Arts and On the Generation of Sounds. These are accompanied by a significant Middle English treatise on the Seven Liberal Arts whose anonymous fifteenth-century author translated and excerpted passages from Grosseteste's treatises in a re-imagining of their structure and function.0Each work is treated separately within the volume, which is constructed in three parts. On the Liberal Arts sets Grosseteste's thoughts on the arts subjects and emphasises moral concerns about the purpose of learning. On the Generation of Sounds builds on the theories and statements of On the Liberal Arts in connection to the production of sound, elaborating the earlier position, relating the generation of sounds to human vocal and speech production. (shrink)

Despite a large and multifaceted effort to understand the vast landscape of phenotypic data, their current form inhibits productive data analysis. The lack of a community-wide, consensus-based, human- and machine-interpretable language for describing phenotypes and their genomic and environmental contexts is perhaps the most pressing scientific bottleneck to integration across many key fields in biology, including genomics, systems biology, development, medicine, evolution, ecology, and systematics. Here we survey the current phenomics landscape, including data resources and handling, and the progress that (...) has been made to accurately capture relevant data descriptions for phenotypes. We present an example of the kind of integration across domains that computable phenotypes would enable, and we call upon the broader biology community, publishers, and relevant funding agencies to support efforts to surmount today's data barriers and facilitate analytical reproducibility. (shrink)

ABSTRACT:A wide range of research uses patterns of genetic variation to infer genetic similarity between individuals, typically referred to as genetic ancestry. This research includes inference of human demographic history, understanding the genetic architecture of traits, and predicting disease risk. Researchers are not just structuring an intellectual inquiry when using genetic ancestry, they are also creating analytical frameworks with broader societal ramifications. This essay presents an ethics framework in the spirit of virtue ethics for these researchers: rather than focus on (...) rule following, the framework is designed to build researchers’ capacities to react to the ethical dimensions of their work. The authors identify one overarching principle of intellectual freedom and responsibility, noting that freedom in all its guises comes with responsibility, and they identify and define four principles that collectively uphold researchers’ intellectual responsibility: truthfulness, justice and fairness, anti-racism, and public beneficence. Researchers should bring their practices into alignment with these principles, and to aid this, the authors name three common ways research practices infringe these principles, suggest a step-by-step process for aligning research choices with the principles, provide rules of thumb for achieving alignment, and give a worked case. The essay concludes by identifying support needed by researchers to act in accord with the proposed framework. (shrink)

Biological ontologies are used to organize, curate, and interpret the vast quantities of data arising from biological experiments. While this works well when using a single ontology, integrating multiple ontologies can be problematic, as they are developed independently, which can lead to incompatibilities. The Open Biological and Biomedical Ontologies Foundry was created to address this by facilitating the development, harmonization, application, and sharing of ontologies, guided by a set of overarching principles. One challenge in reaching these goals was that the (...) OBO principles were not originally encoded in a precise fashion, and interpretation was subjective. Here we show how we have addressed this by formally encoding the OBO principles as operational rules and implementing a suite of automated validation checks and a dashboard for objectively evaluating each ontology’s compliance with each principle. This entailed a substantial effort to curate metadata across all ontologies and to coordinate with individual stakeholders. We have applied these checks across the full OBO suite of ontologies, revealing areas where individual ontologies require changes to conform to our principles. Our work demonstrates how a sizable federated community can be organized and evaluated on objective criteria that help improve overall quality and interoperability, which is vital for the sustenance of the OBO project and towards the overall goals of making data FAIR. Competing Interest StatementThe authors have declared no competing interest. (shrink)

An inductive method Cλ in the λ-system of Carnap [1] is immodest, on evidence e, iff its estimate, on e, of its own accuracy is higher than its estimate, on e, of the accuracy of any rival method Cλ′. Immodesty seems to be a condition of stable trust: if you trusted a modest Cλ, you should start by trusting its advice to replace it by a rival that it estimates to be more accurate. One might guess that any Cλ would (...) be immodest on any evidence. But in [2] I proved that, under a certain accuracy measure taken from Carnap [1], §§ 20–21, there would be exactly one immodest Cλ. Unfortunately, that one sometimes turns out to be C0 ; and since nobody in his right mind would trust C0 we are then left with no acceptable Cλ. Stephen Spielman [3] has proposed a remedy: an estimate of accuracy, on evidence e, should disregard accuracy under circumstances that are ruled out by e. Spielman proves that if this change is made, any Cλ is immodest on any evidence. (shrink)

A collection of 13 papers by David Lewis, written on a variety of topics including causation, counterfactuals and indicative conditionals, the direction of time, subjective and objective probability, explanation, perception, free will, and rational decision. The conclusions reached include the claim that time travel is possible, that counterfactual dependence is asymmetrical, that events are properties of spatiotemporal regions, that the Prisoners’ Dilemma is a Newcomb problem, and that causation can be analyzed in terms of counterfactual dependence between events. (...) These papers can be seen as a “prolonged campaign” for a philosophical position Lewis calls “Humean supervenience,” according to which “all there is to the world is a vast mosaic of local matters of particular fact,” with all global features of the world thus supervening on the spatiotemporal arrangement of local qualities. (shrink)

The first volume of this series presents fifteen selected papers dealing with a variety of topics in ontology, philosophy of mind, and philosophy of language.

Many years ago, C.B. Martin drew our attention to the possibility of ‘finkish’ dispositions: dispositions which, if put to the test would not be manifested, but rather would disappear. Thus if x if finkishly disposed to give response r to stimulus s, it is not so that if x were subjected to stimulus r, x would give response z; so finkish dispositions afford a counter‐example to the simplest conditional analysis of dispositions. Martin went on to suggest that finkish dispositions required (...) a theory of primitive causal powers; there, I think, he was mistaken. All that they require is an improved conditional analysis, and this improved analysis can be built upon whatever treatments of properties and of laws we may favour on other grounds. (shrink)

Jaegwon Kim définissait une propriété intrinsèque comme une propriété compatible avec le fait que l’objet ne serait accompagné d’aucun autre être contingent. Mais cela impliquerait que la solitude serait une propriété intrinsèque, or c’est une propriété extrinsèque. Les auteurs définissent une propriété intrinsèque de base comme une propriété indépendante de la solitude et de l’accompagnement et qui n’est ni une propriété disjonctive ni une négation de propriété disjonctive. Deux doubles intrinsèques sont des objets qui ont toutes les mêmes propriétés intrinsèques (...) de base. Une propriété intrinsèque peut dès lors être définie comme une propriété qui ne peut jamais différer entre deux doubles. Cette définition est ensuite appliquée à différents problèmes. Si les lois de la nature sont absolument nécessaires ou qu’un être nécessaire existe, de nombreuses connexions deviendraient alors des propriétés intrinsèques et il sera nécessaire de conserver un sens à la possibilité que ces connexions nécessaires auraient pu ne pas exister. Les propriétés dispositionnelles seront intrinsèques ou non, selon la conception des lois de la nature. Il est possible de suivre les conséquences de la définition, en amendant éventuellement d’autres concepts. La définition peut aussi s’appliquer aux relations. Les auteurs comparent aussi leur définition à d’autres définitions antérieurement données par David Lewis et Peter Vallentyne. (shrink)

Autor eseju argumentuje, że podróże w czasie są możliwe, a paradoksy podróży w czasie są osobliwościami, a nie niemożliwościami. Obrona możliwości podróży w czasie wymaga przyjęcia (a) trwających w czasie rzeczy, które posiadają zarówno przestrzenne, jak i czasowe części, (b) psychologicznej ciągłości i łączności oraz ciągłości przyczynowej jako kryteriów tożsamości osobowej, a także (c) rozróżnienia pomiędzy czasem zewnętrznym i osobistym.

This book has been written in the hopes of equipping teachers-in-training—that is, teacher candidates—with the skills needed for action research: a process that leads to focused, effective, and responsive strategies that help students succeed.

The Search for the Legacy of the USPHS Syphilis Study at Tuskegee is a collection of essays from experts in a variety of fields seeking to redefine the legacy of the infamous Tuskegee Syphilis Study. The essayists place the legacy of the study within the evolution of racial and ethnic relations in the United States. Contributors include two leading historians on the study, two former United States Surgeons General, and other prominent scholars from a wide range of fields.

This book is a collection of secondary essays on America's most important philosophic thinkers—statesmen, judges, writers, educators, and activists—from the colonial period to the present. Each essay is a comprehensive introduction to the thought of a noted American on the fundamental meaning of the American regime.

What did C. S. Lewis think about truth, goodness and beauty? Fifteen essays explore three major philosophical themes from the writings of Lewis--Truth, Goodness and Beauty. This volume provides a comprehensive overview of Lewis's philosophical thinking on arguments for Christianity, the character of God, theodicy, moral goodness, heaven and hell, a theory of literature and the place of the imagination.

Lewis' counterfactual account of deterministic causation has no way in which to represent causal sufficiency. In the case in which the cause and effect actually occur, the conditional, c box-arrow e is trivially true, equivalent to the material conditional. Yet in deterministic causation, one needs a notion of causal sufficiency that is stronger than that.

In "Unnatural Science"(1) Catherine Elgin examines the dilemma which David Lewis sees posed by Putnam's model-theoretic argument against realism. One horn of the dilemma commits us to seeing truth as something all too easily come by, a virtue to be attributed to any theory meeting relatively minimal conditions of adequacy. The other horn commits us to "anti-nominalism", some version of the ancient doctrine that language must "carve nature at the joints": that there are natural kinds or classes which (...) alone qualify as referents (extensions) for our predicates. Elgin offers a searching critique of Lewis' response (accepting the second horn) and an illuminating defence of its contrary: "we cannot construe (mere) truth as the end of scientific inquiry. Not ... because truth is too hard to come by, but because it is too easy" (p. 301). (shrink)

In this essay I argue for a line of descent, in terms of methodology as an apologist, from J.H. Newman to G.K. Chesterton, and hence to C.S. Lewis. I analyse aspects of Chesterton's methodology as an apologist which strongly suggest the influence of Newman. I then argue that Newman may have exercised a greater influence on Lewis's methodology as an apologist, through Chesterton, than has previously been realised. This raises questions for future study concerning Newman's possible influence, not (...) only on Lewis, but on the other Inklings and related thinkers such as Dorothy Sayers. (shrink)

Like many discussions on the pros and cons of epistemic foundationalism, the debate between C. I. Lewis and H. Reichenbach dealt with three concerns: the existence of basic beliefs, their nature, and the way in which beliefs are related. In this paper we concentrate on the third matter, especially on Lewis’s assertion that a probability relation must depend on something that is certain, and Reichenbach’s claim that certainty is never needed. We note that Lewis’s assertion is prima (...) facie ambiguous, but argue that this ambiguity is only apparent if probability theory is viewed within a modal logic. Although there are empirical situations where Reichenbach is right, and others where Lewis’s reasoning seems to be more appropriate, it will become clear that Reichenbach’s stance is the generic one. We conclude that this constitutes a threat to epistemic foundationalism.Keywords: Epistemic foundationalism; Probability; Clarence Irving Lewis; Hans Reichenbach. (shrink)

According to David Lewis’s Modal Realism, other possible worlds really exist as concrete, spatiotemporal systems, and every way that a world could be is a way that some world is. To establish this plenitude of concrete possible worlds, Lewis presents his ‘principle of recombination,’ which is meant to guarantee that there exists a possible world, or part of a possible world, for every possibility. Jessica Wilson has recently argued that Lewis’s principle of recombination fails to generate (...) enough worlds to account for the plenitude of possibilities. Namely, Wilson argues that the principle of recombination cannot account for the possibility of spatially overlapping but distinct fundamental entities, as well as certain macroscopic entities. In this paper, I will defend Lewis’s principle of recombination against these charges, arguing that Wilson’s objections overlook features of Lewisian metaphysics that can solve the problems at hand. (shrink)

This, the 21st volume in the Library of Living Philosophers, is more than Sir Alfred Ayer's final word on the philosophical issues that preoccupied him for more than sixty years; the list of contributors is a roll-call of some of the greatest living figures in philosophy, each expertly addressing a key problem arising in Ayer's work. Most of the critical papers are answered directly and in detail by Sir Alfred-he completed his replies to 21 of the 24 papers before his (...) death. Contributors include: A. J. Ayer, Evandro Agazzi, James Campbell, David S. Clarke, Michael Dummett, Elizabeth Eames, John Foster, Dimitri Ginev, Paul Gochet, Martin Hollis, Ted Honderich, Tscha Hung, Peter Kivy, Arne Naess, D. J. O'Connor, Desiree Park, David Pears, Azarya Polikarov, Hilary Putnam, Francisco Miró, Quesada C., A. Anthony Quinton, Emanuele Riverso, Ernest Sosa, T. L. S. Sprigge, Barry Stroud, and David Wiggins. (shrink)

The revival of analytic metaphysics in the latter half of the twentieth century is typically understood as a consequence of the critiques of logical positivism, Quine’s naturalization of ontology, Kripke’s Naming and Necessity, clarifications of modal notions in logic, and the theoretical exploitation of possible worlds. However, this explanation overlooks the work of metaphysicians at the height of positivism and linguisticism that affected metaphysics of the late twentieth century. Donald C. Williams is one such philosopher. In this paper I explain (...) how Williams’s fundamental ontology and philosophy of time influenced in part the early formation of David Lewis’s metaphysics. Thus, Williams played an important role in the revival of analytic metaphysics. (shrink)

In his deliciously funny book, Medicare Meets Mephistopheles, Professor David Hyman argues that Medicare corrupts our most base impulses. It urges us, for example, to grab for more than our fair share of benefits while offering providers “the prospect of staggering amounts of money – even as…actuaries were promising Congress that the Medicare program would be easily affordable.” Modeled on C.S. Lewis’ The Screwtape Letters, Professor Hyman's satirical examination of Medicare takes the form of a memo to Satan (...) from an underling demon in the Department of Illness and Satanic Services, reporting on the success of Satan's diabolical plot to corrupt humanity. Sprinkled with political cartoons, absurd stories of Medicare's over-the-top fraud enforcement efforts, and a historical account of Medicare's genesis, Medicare Meets Mephistopheles gives us a well-researched and easy-to-read primer on the biggest pot of gold in medicine. (shrink)

In David Lewis’s famous ‘Many, but Almost One’, he argues that when objects of the same kind share most of their parts, they can be counted as one. I argue that mereological overlap does not do the trick. A better candidate is overlap in function. Although mereological overlap often goes hand-in-hand with functional overlap, a functional approach is more accurate in cases in which mereology and function are teased apart. A functional approach also solves a version of the (...) problem of the many that Lewis thought was immune to the Almost-One solution. (shrink)

Milan, David While esteemed Christian apologist C.S. Lewis ruefully puzzled over The Problem of Pain, the theologians invented their own word - 'theodicy' - to describe the futile attempts (to date) to resolve monotheism's conundrum - that of an omnipotent, all-loving deity magisterially presiding over a world in which widespread evil is so pervasive. And what a mind bender this is!

The Mind in Nature has two central aims. First, that of defending a ‘basic ontology’. Second, having advanced a plausible ontological framework, to appeal to it to cast light on the status of intentionality and the nature of consciousness, paying particular attention to the question of what distinguishes conscious systems from those that are vegetative.Central to Martin's basic ontology is his acceptance of a realist conception of dispositionality. Contrary to the view of David Lewis and others, talk about (...) a thing's dispositions cannot be analysed as talk about a thing's behaviour in a set of counterfactual circumstances. The account of dispositions that emerges from Martin's discussion is one according to which a specific disposition is either actual or it is not. To be actual a disposition need not be manifesting any manifestation. Unmanifesting dispositions are not, therefore, unactualized possibilia – a description which, he observes, is more fitting of unmanifested manifestations. In advancing a realist conception of dispositionality, Martin also opposes those who maintain that dispositional properties reduce to …. (shrink)

The following definitions and explanations are decisions formulated arbitrarily in a sense. However, the underlying assumptions serving as a guide to their formulation are found in both pragmatism and logical positivism. Yet there has been some confusion of the difference between definitions, axioms, postulates, etc., and as a result there is a confusion of certain phases of formal and factual knowledge. For example, one notices in C. I. Lewis' works that all formal statements are thought of as “definitive.” A (...) more effective word, I believe, is “prescriptive.” Axioms are prescriptive, yet, as will be seen below, they are not definitions, and no one in practice conceives of them as such, as can be seen in mathematical works. Axioms prescribe the logical relationship between two or more concepts or words. If interpreted, the factual referents of the words, whose logical relations have been prescribed in axioms, are different. This is not the case with definitions. (shrink)

This essay explores aspects of the relationship between imagery and thought in the work of the English apologist G.K. Chesterton (1874‐1936), focusing on the language and imagery of energy and of vision in his work. It attempts to assess both the strengths and the weaknesses of the ways in which imagery and other aspects of this writer's use of language relate to his argumentation. It also explores the possibility that Chesterton's work can shed light on one of the philosophical dimensions (...) of apologetics, namely, apologists’ attempts to present concepts that cannot be explicitly stated, as part of a defence of Christianity. In considering this issue, it brings Chesterton's use of imagery into dialogue with certain images in the work of the philosopher Mary Midgley and the apologist C.S. Lewis. Finally, it draws certain tentative conclusions concerning the role of imagery in relation to argumentation, within the field of apologetics. (shrink)

Arthur Pap was not quite a Logical Empiricist. He wrote his dissertation in philosophy of science under Ernest Nagel, and he published a textbook in the philosophy of science at the end of his tragically short career, but most of his work would be classified as analytic philosophy. More important, he took some stands that went against Logical Empiricist orthodoxy and was a persistent if friendly critic of the movement. Pap diverged most strongly from Logical Empiricism in his theory of (...) a “functional a priori” in which fundamental principles of science are hardened into definitions and act as criteria for further inquiry. Pap was strongly influenced by the pragmatists C. I. Lewis and John Dewey in developing this alternative theory of a priori knowledge. Using Poincaré’s conventionalism as a springboard, Pap attempted to substantiate these views with examples from physics, and this was his largest foray into philosophy of science topics. Pap, as well as Lewis and Dewey, developed an alternative theory of the a priori in the 1950s that never quite took hold, despite the fact that their views are very intriguing and similar to Michael Friedman’s recent work on the constitutive a priori. (shrink)

The aim of this series is to bring together important recent writings in major areas of philosophical inquiry, selected from a variety of sources, mostly periodicals, which may not be conveniently available to the university student or the general reader. The editor of each volume contributes an introductory essay on the items chosen and on the questions with which they deal. A selective bibliography is appended as a guide to further reading. This volume presents a selection of the most important (...) recent writings on the nature of explanation. It covers a broad range of topics from the philosophy of science to the central philosophical terrain of the theory of knowledge. The distinguished contributors include Peter Achinstein, Wesley C. Salmon, Carl G. Hempel, Philip Kitcher, Bas C. van Fraassen, Jaegwon Kim, B. Brody, Timothy McCarthy, Peter Railton, David Lewis, Peter Lipton, James Woodward, and Robert J. Matthews. (shrink)

Pourquoi intituler cette étude : Deleuze, les mouvements aberrants? C'est que, au premier abord, sa philosophie - et celle construite avec Félix Guattari - se présentent comme une sorte d'encyclopédie de mouvements aberrants. C'est ce qu'il a cherché dans le cinéma, dans la peinture, la littérature, les sciences, dans l'histoire des sociétés, dans la philosophie, et partout. Ainsi par exemple, les déformations des figures de Francis Bacon, les non-sens de Lewis Carroll, les lignes destructrices et créatrices des populations nomades (...) à travers l'histoire, la démence du système capitaliste, les processus schizophréniques qui forment l'inconscient, toutes les forces qui traversent la vie et la pensée. Voilà ce qu'il faut d'abord expliquer : la présence de ces mouvements aberrants Mais on ne peut pas s'en tenir là. La philosophie ne peut pas se contenter de les décrire ou d'en dresser la carte, elle doit rendre raison de ces mouvements. D'où un deuxième aspect, tout aussi important : il faut produire les logiques irrationnelles de ces mouvements aberrants. C'est l'une des grandes nouveautés de l'oeuvre de Deleuze et Guattari : créer de nouvelles logiques, loin des modèles rationnels classiques, mais aussi loin de modèles contemporains, comme le marxisme ou le structuralisme orthodoxes des années 1960-1980. Mais ces logiques n'ont rien d'abstrait, au contraire : ce que veulent faire Deleuze et Guattari, c'est dégager les logiques de tous les modes de peuplements de la terre. Par peuplement, il ne faut pas seulement entendre les populations humaines, mais les populations géologiques, animales, cosmiques ou encore les populations mathématiques, esthétiques, philosophiques qui peuplent la pensée des hommes. Quelle est la logique de tous ces peuplements? Poser une telle question, ce n'est pas seulement demander des explications, mais exiger des justifications. Par exemple, pour le capitalisme : de quel droit se déploie-t-il sur la terre? De quel droit s'approprie-t-il nos cerveaux pour le peupler d'images et de sons? De quel droit asservit-il les corps? Aux logiques que le capitalisme met en oeuvre, ne faut-il pas opposer d'autres logiques, celles justement des mouvements aberrants? Dès lors, la philosophie devient inséparable de combats contre toutes les formes d'organisation - politique, sociale, philosophique, esthétique, scientifique - qui tentent de nier, de conjurer, d'écraser l'existence de ces mouvements aberrants. Ce sont ces questions que cette étude examine, en proposant une traversée de toute la philosophie de Deleuze. (shrink)

Are the relations between the property of a thing and its related disposition to react in certain ways, and between the triggering of that disposition and the consequent effect, necessary? Harré and Madden, in their analysis of causal powers, said they are, but their arguments are not persuasive. Humeans like Simon Blackburn deny it. I criticize the Humean position, and argue afresh for their necessity. I note that David Lewis' analysis of causation requires their necessity, though as a (...) confessed Humean he has not admitted this. (shrink)

David Lewis is associated with the controversial thesis that some properties are more eligible than others to be the referents of our predicates solely in virtue of those properties’ being more natural; independently, that is, of anything to do with our patterns of usage of the relevant predicates. On such a view, the natural properties act as ‘reference magnets’. In this paper I explore (though I do not endorse) a related thesis in epistemology: that some propositions are ‘justification (...) magnets’. According to the doctrine of justification magnetism, we have better justification for some propositions than for others solely in virtue of certain features of those propositions; independently, that is, of anything to do with evidential support or cognitive accomplishment. In the course of discussing an objection to justification magnetism I describe (though I do not endorse) a novel approach to epistemology akin to interpretationism in the theory of reference. (shrink)